DATE2024.09.06 #Press Releases
Anti-Alzheimer's Drugs Produced with Hydrogen
--The only byproduct is water. To the future of pharmaceutical production--
Summary
A research group led by Professor Shu Kobayashi of the Department of Chemistry, Graduate School of Science, the University of Tokyo, and Project Professor Haruro Ishitani of the same department have demonstrated the concept of environmentally friendly chemical production based on chemical conversion using molecular hydrogen in the continuous-flow synthesis of the anti-Alzheimer's drug donepezil.
In the production of chemicals, many reagents must be used, most of which are disposed of as co-products. In this research, environmentally friendly synthesis of pharmaceuticals with complex structures was achieved by utilizing chemical transformations using molecular hydrogen as a main reagent. This synthesis is achieved through a multi-step chemical transformation, but only water is discharged (Figure) . This research result is expected to be used as an example for further development of environmentally low-impact chemical manufacturing.
Figure：Donepezil continuous synthesis system
Journals
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Journal name Chemistry, A European Journal Title of paper