DATE2025.03.04 #News
Elucidation of the recognition mechanism of diverse chemokines by the chemokine receptor CXCR2 involved in immune responses
Summary
A research group led by Dr. Fumiya Sano, Graduate School of Science, The University of Tokyo, Assistant Professor Wataru Shihoya, Professor Osamu Nureki, Doctoral student Shirsha Saha, Indian Institute of Technology, and Professor Arun K. Shukla has revealed the mechanism by which a single chemokine receptor recognizes a variety of chemokines.
Chemokines and their receptors play important roles in inflammatory responses, infection defense, and repair of damaged tissues. However, the mechanism of many-to-one signaling, which is the most important feature of chemokine receptors, has not been fully elucidated. In this study, the chemokine receptor CXCR2 was the subject of research, and comprehensive structural and functional analyses were conducted to elucidate the full extent of its signaling. This research is expected to be applied to the design of drugs for cancer and allergy targeting chemokine receptors. These results were published in Molecular Cell on February 19, 2025.
Figure: Three-dimensional structure of the receptor CXCR2 bound to various chemokines
There are a wide variety of chemokines in the body, and they are recognized by many receptors as well. This relationship is not one-to-one; one receptor recognizes multiple chemokines and regulates immune responses through a complex mechanism.
Journals
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Journal name Molecular CellTitle of paper