DATE2026.05.11 #Press Releases

Discovery of a novel factor regulating transcriptional repression

Disclaimer: machine translated by DeepL which may contain errors.

Mechanism of Transcriptional Repression through Regulation of Protein Stability

Summary

　A research group led by Project Researcher Shusei Mori, Associate Professor Soichi Inagaki, and Professor Emeritus Professor Tetsuji Kakutani at the Graduate School of Science, The University of Tokyo, using the plant Arabidopsis thaliana, has revealed that the novel factor MBD8 is required for transcriptional repression by H3K9 dimethylation. MBD8 promotes transcriptional repression by enhancing the protein stability of LDL2, which acts as a transcriptional repressor. This function of MBD8 is expected to be conserved in other plants, and the results of this study will contribute to our understanding of the molecular mechanisms by which plants repress transcription and the developmental processes and environmental response mechanisms that are regulated by this repression.

MBD8 enhances the protein stability of LDL2 and functions in transcriptional repression

Publication Information

Journal name	Nucleic Acids Research
Title of paper	MBD8 is required for LDL2-mediated transcriptional repression downstream of H3K9me2 in Arabidopsis
Author(s)	Shusei Mori*, Akihisa Osakabe, Juliarni, Yuriko Tanaka, Mami Hirayama, Soichi Inagaki*, Tetsuji Kakutani* (*Responsible Author)
DOI number	10.1093/nar/gkag361