DATE2025.04.01 #Press Releases

Ligand recognition and downstream signal selection mechanisms of CXCR3 and CXCR7 involved in immune responses.

Disclaimer: machine translated by DeepL which may contain errors.

Summary

A research group led by Dr. Fumiya Sano, Assistant Professor Wataru Shihoya, and Professor Osamu Nureki at the Graduate School of Science, The University of Tokyo, and Dr. Shirsha Saha and Professor Arun K. Shukla at the Indian Institute of Technology, has elucidated how the membrane receptor CXCR3, which is responsible for immune responses, recognizes ligands and activates two different downstream The research group led by Prof. Arun K. Shukla and his colleagues has elucidated the mechanism by which CXCR3, a membrane receptor responsible for immune responses, recognizes ligands and activates two different downstream signals in a deflective manner based on its steric structure. In addition, they comprehensively investigated the downstream signaling of CXCR7, another receptor activated by a ligand common to CXCR3.

Figure: Three-dimensional structure of the receptor CXCR3 in the ligand-free state and bound to the agonist

Journal

Journal name	Nature Communications
Title of paper	Molecular insights into dual-agonism and biased-signaling at the C-X-C type chemokine receptors CXCR3 and CXCR7