DATE2025.01.10 #Press Releases
Identification of all proteins created during cell proliferation
——Translatome analysis using eukaryotes with simple structures——
Summary
A research group led by Yuko Mogi, Research Fellow (at the time of the research), Yuiki Kondo, Graduate Student, Tetsuya Higashiyama, Professor and Yamato Yoshida, Associate Professor at the Graduate School of Science, The University of Tokyo, and Toshifumi Inada and Yoshitaka Matsuo, Professors and Associate Professors at the Department of RNA Regulation, The University of Tokyo, Institute of Medical Science, University of Tokyo, has revealed an overall picture of protein translation in unicellular eukaryotes using Ribosome Profiling' technology, which visualises the state of mRNA translation by the ribosome, has revealed an overall picture of protein translation in unicellular eukaryotes. This analysis allowed the comparison of ribosomal footprints (mRNA fragments protected by ribosomes) in non-mitotic and mitotic cells, and successfully identified a group of genes that are specifically translated during cell division with a high degree of accuracy. In addition, the identified genes include a number of genes of unknown function that are conserved in different eukaryotes, including humans. In the future, clarification of the molecular functions of these genes is expected to provide important clues to the mechanisms common to eukaryotic cell division.
Figure: Identification of all types of proteins translated during the creation of new cells
Links：Institute of Medical Science, University of Tokyo
Journal
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Journal name Proceedings of the Japan Academy Series BTitle of paper