DATE2024.09.05 #Press Releases
Suppression of Off-Target Effects by a Novel Modified siRNA
- Development of siRNA Drugs with Fewer Side Effects for the Treatment of Genetic Disorders-
Summary
A research group led by Professor Hiroshi Abe and doctoral student Kohei Nomura of the Graduate School of Science, Nagoya University, in collaboration with doctoral student Seongjin An of the Graduate School of Frontier Sciences, the University of Tokyo, and Associate Professor Kumiko Ui-Tei of the School of Science, the University of Tokyo (at the time of the research, currently a specially appointed researcher), has developed a new molecular structure for siRNA medicine, We have devised a new molecular structure, 2'-formamide-modified nucleic acid, and developed an siRNA drug with no side effects.
This achievement can be applied to siRNA drugs for various diseases, and is expected to be used as a safe and secure domestically produced siRNA drug with fewer side effects.
The research results were published in Nucleic Acids Research, a journal published by Oxford University Press, on September 5, 2024 at 9:01 a.m. (Japan Standard Time).
Figure：Mechanism of off-target effects and suppression by chemical modification
Iinks：Nagoya University, Graduate School of Frontier Sciences, the University of Tokyo.（in Japanese)
Journal
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Journal name Nucleic Acids ResearchTitle of paper