DATE2024.05.17 #Press Releases
Model selection reveals selective regulation of blood amino acid and lipid metabolism by insulin in humans
--Metabolic regulation by insulin after after ingestion differs between amino acids and lipids--
Summary of Presentations
A research group led by Suguru Fujita, a project researcher (current affiliation: Graduate School of Agricultural and Life Sciences), Kenichi Hironaka, a visiting researcher, and Professor Shinya Kuroda, all from the Graduate School of Science, The University of Tokyo, in collaboration with Yasuaki Karasawa, a visiting researcher from the Department of Neurosurgery, The University of Tokyo Hospital, conducted a study on the response of blood metabolites to oral glucose ingestion. By constructing several simple mathematical models representing the metabolic regulation by insulin and selecting models, they identified differences in the effective regulation of insulin on blood amino acid and lipid metabolism (Fig. 1). As it is known that insulin's metabolic regulation of blood amino acids and lipids is disrupted in patients with obesity and type 2 diabetes, in addition to blood glucose, the findings may provide valuable insights into metabolic abnormalities in the condition and the potential for therapeutic intervention.
Figure: Differences between selected model structures of amino acids and lipids.
By developping multiple mathematical models and selecting the model that best reflects the clinical data, the regulatory structures of amino acids and lipids were identified, where A represents blood metabolites and Y represents the effective insulin that regulates blood metabolites. In the time series, red dots represent clinical data and black lines represent simulated values.
Journals
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Journal name iScience Title of paper