UI-TEI Kumiko


程 久美子 （てい くみこ）
UI-TEI Kumiko

UI-TEI Kumiko
Title Associate Professor
Affiliation Department of Biophysics and Biochemistry, Department of Bioinformatics and Systems Biology (UG), Department of Biological Sciences (GR), Graduate School of Science
E-mail
Room 419A, Faculty of Science Bldg.3, 4F
TEL +81-3-5841-3043 　|　23043（ext.）


Research Field

Genome Information Biology, Molecular Biology

Research Subject

Regulation of Small RNA Machinery Systematic Analysis of Gene Function

Current Research

Small RNAs are protein-noncoding RNA molecules that control gene expression by mediating mRNA degradation, translational inhibition, or chromatin modification. My main interest is to elucidate the molecular basis of gene regulation by tiny protein-noncoding RNAs including short interfering RNAs (siRNAs) and microRNAs (miRNAs). We established the guidelines for the selection of highly effective siRNA sequences for RNA interference, analyzed the position-dependent functions of ribonucleotides in siRNAs, and found that the thermodynamic stability in the seed duplex is a primary determinant of the efficiency of the siRNA-based off-target effects. Based on these outcomes of our researches, I am going to clarify the regulatory machinery of small RNAs on gene expression.

Keywords

Small RNA, siRNA, miRNA, Gene Function, RNA silencing, non-coding RNA

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