SHIMIZU Kimiko


清水 貴美子しみず きみこ
SHIMIZU Kimiko

SHIMIZU Kimiko
Title Assistant Professor
Affiliation Department of Biophysics and Biochemistry, Department of Biophysics and Biochemistry (UG), Department of Biological Sciences (GR), Graduate School of Science
E-mail
Room 214, Faculty of Science Bldg.3, 2F
TEL +81-3-5841-4382 | 24382(ext.)


Research Field

Neuroscience

Research Subject

Molecular approaches to circadian regulation of the long-term memory formation

Current Research

Evidence from several studies demonstrates that circadian rhythm affects memory formation. However it is not yet clear if the internal clock regulates the memory formation, and there is no substantial molecular evidence to connect these two brain functions.SCOP is expressed in a circadian manner in the suprachiasmatic nucleus (SCN) that is the center for circadian rhythm. SCOP negatively regulates K-Ras function and its downstream ERK/MAPK signaling. In the hippocampus, SCOP is critical for long-term memory formation for novel objects. I am trying to find a molecular process between circadian rhythm and memory formation, focusing on SCOP and related molecules

Keywords

SCOP, K-Ras, circadian rhythm, memory, suprachiasmatic nucleus, hippocampus

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