FUKADA Yoshitaka


深田 吉孝ふかだ よしたか
FUKADA Yoshitaka

FUKADA Yoshitaka
Title Professor
Affiliation Department of Biophysics and Biochemistry (UG), Department of Biological Sciences (GR), Graduate School of Science
E-mail
Room 218A, Faculty of Science Bldg.3, 2F
TEL +81-3-5841-4381 | 24381(ext.)


Research Field

Molecular Biology, Neuroscience, Animal Physiology and Biochemistry

Research Subject

Molecular mechanisms of circadian clock systems in the brain and peripheral tissues and light-signal transduction in the retina and extra-retinal tissues.

Current Research

By using biochemical, molecular biological and transgenic techniques, we are studying light signal transduction processes in retinal rod/cone photoreceptor cells, and investigating the molecular link between the photic-input pathway and the circadian oscillator at central clock tissues such as chick and zebrafish pineal gland and rodent suprachiasmatic nucleus (SCN) of the hypothalamus.<br>
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(1) We are studying the structures and functions of new clock(-related) genes for understanding the molecular nature of transcription/translation-based autoregulatory feedback loop of the circadian oscillator in cells and their coupling in higher vertebrates. Light-dark cycles and many other factors including food uptake and sleep-awake cycles entrain the circadian clock system. We are interested in molecular level studies on the photic and non-photic input pathways toward the oscillator. <br>
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(2) A photon signal captured by photoreceptive molecules such as rhodopsin triggers a sequential activation of G-protein (transducin), cGMP-phosphodiesterase, and cGMP-gated cation channel, resulting in generation of receptor potential. We are interested in the difference in molecular mechanism and properties of signal-transducing proteins between rod and cone photoreceptor cells, which are responsible for twilight and daylight (color) vision, respectively. We are also pursuing physiological roles of non-visual photoreceptive molecules in the light-sensitive animal physiology such as body color change of animals. <br>
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(3) The alpha- and gamma-subunits of G-proteins are modified with fatty acids and isoprenoid, respectively. These lipids are absolutely required for the signal-transducing function of G-proteins, and we are interested in the mode of interaction between the modifying lipid and protein and/or membranes.

Keywords

Circadian rhythm, Circadian clock, Brain function, Hypothalamus, Suprachasmatic nucleus, Pineal gland, Transcriptional regulation, Light signaling, Protein phosphorylation, Posttranslational modification, G-protein, (Mouse, Chicken, Zebrafish)

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