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Research Field
Molecular genetics
Research Subject
Stress responses of yeast
Current Research
Cells respond and adapt to various extracellular changes. Environmental stresses, such as high osmolarity and acute glucose deprivation, rapidly and transiently shut down translation initiation and actin polarization in the yeast Saccharomyces cerevisiae. The biological significance of transient shutdown is considered to facilitate the spatial rearrangement of gene expression in response to environmental stress. Certain clinical drugs, such as local anesthetics and antipsychotic phenothiazines, and cationic surfactants also cause shutdowns similar to those triggered by the environmental stresses. The aim of my study is to elucidate mechanism of the shutdowns elicited by the stresses and the drugs.
Keywords
yeast, osmotic stress, glucose deprivation, actin, translation initiation