Protein folding is a process in which an extended polypeptide chain acquires a unique folded conformation with biological activity. Clarifying the mechanism of protein folding is essential for improving our understanding of the structure and function of proteins. It is also important because many critical biological processes and disease states involve protein misfolding and aggregation reactions. History, basic concepts and methods and current topics for understanding protein folding and misfolding will be addressed.
Students understand history, basic concepts, methods and current topics of protein folding and misfolding.

1. Protein folding and misfolding (10/14)
2. Forces responsible for protein folding and misfolding (10/14)
3. Mechanism of protein folding and stability of proteins (10/23)
4. Folding diseases(10/23)
and other related topics

• 1. Protein folding and misfolding (10/14)
• 2. Forces responsible for protein folding and misfolding (10/14)
• 3. Mechanism of protein folding and stability of proteins (10/23)
• 4. Folding diseases(10/23)
• and other related topics

Students study by themselves articles and topics related to history, basic concepts and methods of protein folding and misfolding.
The topics to be introduced and discussed in this course are the stability of proteins, the mechanism of protein folding and misfolding, its biological significance, and interactions and forces responsible for protein folding and misfolding. Various physicochemical approaches including CD, fluorescence, NMR, and calorimetry are addressed.

• 講義室
  • 吹田キャンパス蛋白質研究所 蛋白研１階講堂
    Institute for Protein Research, Suita Campus
• 日時
  • 07/13 10:30 ～ 07/13 17:50
    Jul 13, 10:30 ～ Jul 13, 17:50