From People - School of Science, The University of Tokyo
清水 貴美子 (しみず きみこ)
SHIMIZU, Kimiko
| Title | Assistant Professor |
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| Affiliation | Department of Biophysics and Biochemistry, Graduate School of Science |
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| Room | 214, Faculty of Science Bldg.3, 2F |
| TEL | +81-3-5841-4382 24382 (ext.) |
Research Field
Neuroscience
Research Subject
Molecular approaches to circadian regulation of the long-term memory formation
Current Research
Evidence from several studies demonstrates that circadian rhythm affects memory formation. However it is not yet clear if the internal clock regulates the memory formation, and there is no substantial molecular evidence to connect these two brain functions.SCOP is expressed in a circadian manner in the suprachiasmatic nucleus (SCN) that is the center for circadian rhythm. SCOP negatively regulates K-Ras function and its downstream ERK/MAPK signaling. In the hippocampus, SCOP is critical for long-term memory formation for novel objects. I am trying to find a molecular process between circadian rhythm and memory formation, focusing on SCOP and related molecules.
Keywords
SCOP, K-Ras, circadian rhythm, memory, suprachiasmatic nucleus, hippocampus