From People - School of Science, The University of Tokyo

廣野 雅文 (ひろの まさふみ)
HIRONO, Masafumi

Title	Associate Professor
Affiliation	Department of Biological Sciences (Zoological Science), Graduate School of Science
Room	142, Faculty of Science Bldg.2, 1F
TEL	+81-3-5841-4429 24429 (ext.)

Research Field

Cell Biology, Molecular Biology

Research Subject

Assembly Mechanism of the Centriole

Current Research

Centrioles are organelles that have a characteristic structure with nine triplet microtubules and assemble in a semi-conservative fashion once per cell cycle. How the structure is assembled is a long-standing question in cell biology. To understand the molecular mechanism of the centriole biogenesis. we take genetic and molecular cell biological approaches using Chlamydomonas. In particular, our research interests are in phenotypic analyses of centriole-deficient mutants, identification of their mutated genes, biochemical analysis of isolated centrioles, and functional analyses of proteins essential for the centriole formation.

Keywords

Centriole, Chlamydomonas, Flagellar basal body, Mutant, Self-replication, Centrosome, Microtubule, Spindle, Cell division, Cytoskeleton