From People - School of Science, The University of Tokyo

Research Field

Neurobiology, Electrophysiology

Research Subject

Celllar and Molecular Physiology of Neuromodulatory Action of Peptidergic Neurons

Current Research

1. Excitation-Secretion coupling of single peptidergic neuron using primary culture system of Gonadotropin releasing hormone (GnRH) neuron (Single neuron level).

2. Neuromodulatory action of GnRH (or kisspeptin) peptides on CNS circuit (Single neuron ~ neuronal circuit level).

3. Firing activity of neuromodulatory peptidergic neuron during innate characteristic behavior (technical development, in vivo study).

Recent Publications

Abe, H. and Oka, Y. (2009) Primary culture of the isolated terminal nerve - GnRH neurones derived from adult teleost (dwarf gourami, Colisa lalia) brain for the study of peptide release mechanisms. J. Neuroendocrinol. 21: 489-505.

Abe, H., Keen, K.L., and Terasawa, E. (2008) Rapid action of estrogen on intracellular calcium oscillations in primate LHRH-1 neurons. Endocrinology 149: 1155-1162.

Abe, H. and Oka, Y. (2007) Neuromodulatory functions of terminal nerve-GnRH neurons. In : "Fish Physiology Vol. 25, Sensory Systems Neuroscience" (ed. By T.J. Hara and B. Zielenski), Elsevier Inc., San Diego, pp. 455-503.

Abe, H. and Terasawa, E. (2005) Firing Pattern and Rapid Modulation of Activity by Estrogen in Primate LHRH-1 Neurons. Endocrinology, 146:4312-4320.

Tateyama, M., Abe, H., Nakata, H., Saito, O., and Kubo, Y. (2004) Ligand-induced dynamic rearrangement of the intracellular dimeric conformation of metabotropic glutamate receptor1α. Nature Structural & Molecular Biology, 11:637-42.

Keywords

Neuromodulation, Neuronal information processing, secretion, exocytois, ion channel, GPCR, Gonadotropin releasing hirmone (GnRH), peptide, electrophysiology, functional imaging, cell culture

Links

• Lab. page